Transcriptional co-regulators interact specifically and non-covalently with one or multiple DNA-binding transcription factors (TFs) to either activate or repress the transcription of specific genes. The transcriptional co-activator steroid receptor coactivator 1 (SRC-1) is a highly flexible nuclear receptor coregulator that regulates gene expression and can interact with many families of transcription factors, and is often found to be overexpressed in many cancers.
Signosis has developed TF-Coregulator SRC-1 Interaction Plate Array Assay I, allowing for high throughput studying of co-regulator interaction networks with 48 different TFs.