Transcriptional co-regulators interact specifically and non-covalently with one or multiple DNA-binding transcription factors (TFs) to either activate or repress the transcription of specific genes. CBP is a transcriptional coactivator that physically interacts with diverse transcription factors and regulate gene expression.  
Signosis has developed TF-Coregulator CBP Interaction Plate Array Assay I, allowing for high throughput studying of co-regulator interaction networks with 48 different TFs.