Transcription factor E3 (TFE3) is a member of the basic helix-loop-helix family of transcription factors and is involved in regulating various cellular processes, including cell growth, stress responses, and metabolism. The TFE3 luciferase reporter vector is designed to study the transcriptional activity of TFE3. The vector contains a TFE3 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report TFE3 activity while maintaining a low basal level of transcription.