SRY-box transcription factor 18 (SOX18) is a transcription factor that plays a critical role in the development of several tissue types, particularly in vascular development, angiogenesis, vascular smooth muscle cells, and lymphatic development. The SOX18 luciferase reporter vector is designed to study the transcriptional activity of SOX18. The vector contains a SOX18 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report SOX18 activity while maintaining a low basal level of transcription.