cAMP response element-binding protein (CREB) is a transcription factor involved in numerous cellular processes such as gene expression, cell survival, differentiation, and memory formation. The CREB luciferase reporter vector is designed to study the transcriptional activity of CREB. The vector contains a CREB DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report CREB activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.