NRF2/ARE Responsive Secreted Luciferase Reporter HEK293 Cell Line is derived from Human embyronic kidney, and stably express the Gaussia Luciferase reporter gene under the control of NRF2/ARE response element. This cell line is an ideal cellular model for monitoring the activation of Antioxidant response Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown.
 
Secreted reporter stable cell lines are powerful tools in modern biological research, offering unique advantages for studying gene expression and cellular signaling pathways. These cell lines are engineered to stably express a secreted luciferase reporter gene, typically under the control of a specific promoter or response element of interest. The secreted nature of the reporter protein allows for non-invasive, real-time monitoring of gene activation without the need for cell lysis. This enables researchers to perform continuous, long-term studies and repeated measurements from the same cell population. The high sensitivity of secreted luciferases, such as Gaussia luciferase, allows for detection of even subtle changes in gene expression.
 
These stable cell lines are particularly valuable for high-throughput screening, drug discovery, and the study of various cellular pathways, offering a streamlined workflow and compatibility with multiple downstream analyses. Their ability to provide dynamic, quantitative data on gene activation makes them an indispensable asset in fields ranging from cancer research to toxicology studies.