The NeuroMood Stress Pathway represents a multifactorial disorder influenced by the interplay of environmental stressors, genetic predispositions, and intricate intracellular signaling networks. Central to this process is a cascade of transcription factors (TFs) that regulate cellular responses to stress, inflammation, neuroplasticity, and apoptosis. Dysregulation of these TFs is closely linked to the pathophysiology of depression and mood disorders.
A deeper understanding of the TFs involved in stress response pathways is crucial for advancing depression research and therapeutic development. The Signosis, Inc. NeuroMood Stress Pathway TF Activation Profiling Plate Array provides a comprehensive solution for simultaneously analyzing the activity of 16 key TFs, including NF-κB, CREB, AP-1, STAT3, HIF-1α, NRF2, GLI, EGR1, MYC, FOXO3, p53, ATF3, NURR1, SMADs, C/EBP, and KLFs.