Platelet-derived growth factor (PDGF) is a growth factor that is important to embryonic development, cell proliferation, and cell migration, particularly, in blood vessel formation (angiogenesis). Like VEGF, PDGF is able to independently initiate angiogenesis and mediate blood vessel growth and behavior. The protein is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). It has been shown that the cis oncogene is derived from the PDGF B-chain gene. It binds to PDGF receptors, which activate signal transduction pathways such as the PI3K pathway, and subsequently regulate downstream gene expression and the cell cycle. PDGF has also been linked to several diseases such as atherosclerosis, fibrosis and malignant diseases.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    10 pg/mL