Transforming growth factor beta isoforms, TGF-β1, TGF-β2, and TGF-β3 play an important role in tissue homeostasis as wells as embryogenesis. Although these three isoforms share similar amino acid sequence and have similar bioactivities in vitro, they behave distinctly in vivo. Knock-out studies have shown that TGF-β1 is responsible for angiogenesis while TGF-β2 is needed for organ developments and TGF-β3 is necessary for normal palate development. In tumorigenesis, three isoforms can be observed to be regulated differently, for example, TGF-β1 is up-regulated at 3-8 fold while TGF-β3 is down-regulated at 2-3 fold in mammary gland tumor cells. Signosis' TGF-beta ELISA kits can simultaneously analyze TGF-β1 or TGF-β3. Each well is coated with a specific capture antibody to detect corresponding cytokine in the sample. The expression levels of these cytokines can be quantitatively compared between samples.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    8 pg/mL