Adipocytokines are a group of diverse effector molecules that are produced by adipose cells. Abnormal expression of adipokines such as Resistin is associated with the development of insulin resistance, diabetes and other metabolic and cardiovascular disorders in man. Mouse Resistin was described as a novel obesity-mediated adipocytokine that impairs glucose homeostasis by affecting both insulin-stimulated glucose uptake in adipose tissue and hepatic glucose production during fasting. However, there were initially two opposite views on human Resistin. Some studies have shown the correlations between Resistin and obesity. Serum Resistin levels increase with increased adiposity and conversely, decline with decreased adiposity following medical treatment. However, other studies presented contradictory evidences that significantly decreased serum concentrations of resistin with increased adiposity. Resistin has also been shown to increase the expression of several pro-inflammatory cytokines including IL-1, IL-6, IL-12, and TNFα via NF-κB.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    8 pg/mL