Plasminogen activator inhibitor 1 (PAI-1) is a member of a family of proteins that inhibit plasminogen activators. It is a single-chain glycoprotein with a molecular weight of 47 kDa. PAI-1 is the primary inhibitor of tPA and other plasminogen activators in the blood. PAI-1 is mainly produced by the endothelial cells. PAI-1 is also synthesized by adipose tissue. The production of PAI-1 by adipose tissue that elevates plasma PAI-1 levels was observed in insulin resistant patients. Increased PAI-1 levels have been shown to be associated with a number of atherosclerotic risk factors. Insulin and proinsulin correlate with PAI-1 levels. Patients with insulin resistance syndrome and diabetes mellitus tend to have increased PAI-1 levels. Weight loss and treatment aimed at lowering triglyceride and/or cholesterol levels have also been shown to lower PAI-1 levels.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    8 pg/mL