The presence of antibodies against the SSB (also known as La) antigen has been advocated as a diagnostic marker for Sjögren’s syndrome (SS), an autoimmune disease characterized by inflammation of the glands leading to diminished or absent glandular secretion. SS may present as a primary disease or associate with other systemic autoimmune diseases as secondary SS. The SSB antigen is a 47 kD ribonucleic protein associated with a spectrum of small RNAs and primarily resides in the nucleus. Antibodies to the SSB antigen appear in more than 80% of patients with primary or secondary SS. Anti-SSB antibodies usually co-present with anti-SSA antibodies, however due to more common of anti-SSA antibodies in other rheumatological conditions such as systemic lupus erythematosis (SLE) and mixed connective tissue disease (MCTD). It suggests that anti-SSB is more specific for primary and secondary SS than anti-SSA.