Description(s):
The proto-oncogene human epidermal growth factor receptor 2 (HER2) gene also known as ERBB2 is a member of the ERBB/HER RTK family which is comprised of EGFR (EGFR/HER1/ERBB1), HER3/ERBB3, and HER4/ERBB4. This gene encodes for a transmembrane glycoprotein receptor with an intracellular domain with tyrosine kinase activity which is responsible for the activation of intracellular signal transduction pathways controlling epithelial cell growth, differentiation, and angiogenesis. Aberrations of the HER2 gene which usually leads to increased receptor signaling have been observed in many different types of cancer.
 
The HER-2 receptor undergoes a proteolytic cleavage generating an NH2-terminally truncated fragment, p95HER-2, that is membrane-associated and tyrosine-phosphorylated. It has been shown that p95HER-2, but not the full-length receptor correlated with enhanced metastatic potential and significantly worse outcomes in some breast cancer patients.
 
The cell line can be used for studying ErbB/HER signaling pathway.
The cell line can be used for screening or evaluating related drugs/compounds.
The cell line is viral-vector free.
Transfected Her2 gene sequence and its expressed protein have been confirmed.
The cell line is mycoplasma-free.