Autoimmune diseases are a group of chronic conditions in which the body’s immune system mistakenly attacks its own cells and tissues, leading to inflammation, tissue damage, and dysfunction. Common autoimmune diseases include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1D), and psoriasis, among others. These diseases are characterized by a complex dysregulation of immune responses, and a key driver of this dysfunction is the activation of various transcription factors (TFs).
The Autoimmune Disease TF Activation Profiling Plate Array developed by Signosis, Inc. allows researchers to monitor the activation of 16 key TFs implicated in autoimmune disease pathogenesis. This array provides a powerful tool for studying TFs such as NF-κB, FOXP3, STAT, T-bet (TBX21), IRF5, GATA3, Ets1, BLIMP1 (PRDM1), AP-1, PAX5, RORγt, STAT1/STAT3, NOR1, Aire, BATF, and Nur77 which regulate crucial immune responses like inflammation, cell signaling, and immune cell activation.