Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell division and death. Mutations in EGFR gene that lead to overexpression of the protein have been associated with a number of different cancers. The EGFR gene is present on chromosome 7p11.2 and has 28 coding exons in which exons 5–7 and 13–16 code for the ligand binding domain and exons 18–24 code for the TK domain. Downstream effects of EGFR activation include modulation of three major pathways of RAS-RAF-MAPK, PI3K/AKT and JAK/STAT pathways which can lead to cell survival, proliferation and migration of cancer cells.
We offer a collection of unique cloning and expression cDNA vectors contain WT and mutated EGFR gene. These mutations are clinically approved and are under further investigation by many researchers. Our high quality vectors are fully sequenced and are ready to use. We also offer custom cloning services for your specific construct needs.
- Panel of EGFR Mutant Vectors - The panel includes more than 12 ready to go EGFR mutants.
- DYKDDDDK-tag for easy detection - This tag is engineered to downstream of EGFR gene to facilitate Western blot
- perfect for stable cell line establishment - The hygromycin resistant gene is embedded in the vector for stable cell line establishment.
- Custom service available - We also offer the custom service with the same list price. If you have any mutants in your mind, please let us know.
|Product Name||Catalog #||Price||Qty|
|EGFR Exon 19 Deletion||EV-0008||$1,200|
|EGFR Exon 19 Insertion||EV-0010||$1,200|
|EGFR Exon 20 Insertion||EV-0011||$1,200|
|EGFR (T790M C797S)||EV-0013||$1,500|
|EGFR (T790M C797S Exon 19 Deletion)||EV-0014||$1,500|