Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. Deregulation of IL-6 production is implicated in the pathology of several disease processes. Its levels are observed in several diseases, including rheumatoid arthritis (RA). IL-6 plays roles in both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. In addition, like TNFα, IL-6 is another adipocyte secretory product that may be involved in insulin resistance. IL-6 is a cytokine secreted by many cells, including adipocytes and adipose stromal cells. IL-6 secretion is increased in the adipocytes of obese subjects and may be important either as a circulating hormone or as a local regulator of insulin action. IL-6 has been implicated in the development of insulin resistance and type 2 diabetes in obese individuals. Like TNFα, IL-6 inhibits the expression of LPL, but, unlike TNFα, IL-6 does not stimulate lipolysis.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    4 pg/mL