Neurodegenerative diseases are a group of disorders that cause a progressive loss of function in neurons, leading to cognitive decline, motor dysfunction, and other neurological symptoms. Parkinson's disease, Alzheimer's disease, and Huntington's disease are three of the most common neurodegenerative diseases.
 
Proteostasis, or protein homeostasis, is a key factor in the development and progression of neurodegenerative diseases. Misfolded or aggregated proteins can accumulate in the brain, leading to the formation of toxic protein aggregates and disrupting normal cellular processes.
 
Transcription factors play an important role in regulating proteostasis, controlling the expression of genes involved in protein synthesis, folding, trafficking, and degradation. Signosis has developed the Neurodegenerative Disease Transcription Factor Activation Plate Array to analyze the activities of 15 neurodegenerative disease-related transcription factors simultaneously in mammalian samples. The array includes transcription factors such as AP1, CREB, ER, FOXO, FOXA1, GATA, HSF1, NFKB, NRF2, NURR1, PITX3, PPAR, SP1, TBP, and XBP1. By profiling the activation of these transcription factors, researchers can gain a better understanding of the underlying mechanisms of neurodegenerative diseases and potentially identify new therapeutic targets.