|Product Name||Catalog #||Price||Qty|
|Neurodegenerative Disease TF Activation Profiling Plate Array||FA-1013||$629|
Neurodegenerative disease, include Parkinson’s, Alzheimer’s and Huntington’s disease, is a disease that directly affect the neurons in the human brain, which result in progressive degeneration and / or death of nerve cells. This disease is associated with the accumulation of misfolded proteins which affect proteostasis. Multiple transcription factors and target genes have been widely reported to associate with proteostasis, including protein synthesis, folding, trafficking and degradation. Signosis has developed Neurodegenerative Disease Transcription Factor Activation Plate Array to analyze the activities of 15 Neurodegenerative Disease-related TFs simultaneously in mammalian samples, including AP1, CREB, ER, FOXO, FOXA1, GATA, HSF1, NFKB, NRF2, NRRR1, PITX3, PPAR, SP1, TBP, XBP1.
List of Applicable TFs:
Signosis’ TF Activation Profiling Arrays are used for monitoring the activities of multiple TFs simultaneously. In the technology, a series of biotin-labeled probes are made based on the consensus sequences of TF DNA-binding sites. When the probe mixtures incubate with nuclear extracts, individual probes will find their corresponding TFs and form TF/probe complexes, which can be easily separated from free probes through a simple spin column purification. The bound probes are then detached from the complexes and analyzed through hybridization with a plate, which each well is specifically pre-coated with complementary sequences of the probes.