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Anti-dsDNA antibodies are characteristic of systemic lupus erythematosus (SLE) and appear to be critical in the pathogenesis of tissue injury. There is a good correlation between anti-dsDNA antibody levels and disease activity. The overall detection rate of these antibodies is approximately 50-55% in SLE patients and about 89% in SLE patients with active renal disease. When they are present in high concentration, anti-dsDNA antibodies are virtually specific for SLE (>90%). Antibodies to dsDNA may disappear with immunosuppressive treatment and during remission. They rarely occur in other autoimmune disorders. Signosis has developed anti-dsDNA ELISA, a sandwich quantitative assay, to screen for the presence of serum ds-DNA antibodies IgG. 

 

Detection Range:
    4 - 125 ng/mL

Sensitivity:
    0.5 ng/mL

Mouse Anti-dsDNA ELISA Kit

SKU: EA-5201
$570.00Price

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