NFkB is a ubiquitous transcription factor that plays a key role in cellular responses to numerous stimuli such as stress, cytokines, ultraviolet irradiation, and bacterial or viral antigens. Incorrect regulation of NFkB has been linked to cancer, inflammatory and autoimmune diseases, and septic shock. When NFkB is activated, it dissociates from its inhibitor IkB and moves from the cytoplasm to the nucleus.  Once in the nucleus, it binds to target DNA elements and positively regulates the transcription of genes involved in immune and inflammatory responses, cell growth control, and apoptosis.Signosis has developed a plate-based array for profiling 20+ NFkB-regulated genes. By using this assay, researchers are able to compare gene expression in up to three samples on a single microtiter plate.