Kinome represents a small fraction of the human genome (about 2%), however, each of the 518 kinases plays an integral role in many biological processes such as cellular growth, differentiation, gene expression, migration, immunity and inflammation.   As signal transducers, kinase activities are tightly regulated to ensure proper cellular functions.  Disruption in the activity levels can lead to a variety of diseases, including arthritis, liver disease, inflammatory bowel disease, cardiac-related diseases, and cancers.  Therefore, tools to study kinase pathways and activities can improve our understanding of kinases and facilitate drug discoveries.   


Signosis
provides a number of tools to study kinase activity, or to monitor kinase pathways.

Kinase TAD Luciferase Reporter Stable Cell Line

Benefits:

  • Routine mycoplasma testing - All cell lines tested negative for mycoplasma.
  • High sensitive and responsive - Each cell line is validated to induce strong reporter signal.
  • Consistent - Kinase-TAD reporter construct is stably integrated into the genome to avoid experimental/cell-to-cell variations.
  • Time saving - Cell line can be used for experiments right away to study different signaling pathways.
Product Name Catalog # Price (FP)* Catalog # Price (NP)**   Qty
ELK-TAD Luciferase Reporter HEK293 Stable Cell Line SL-0040-FP $2,000 SL-0040-NP $950
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ELK-TAD Luciferase Reporter Hela Stable Cell Line SL-0041-FP $2,000 SL-0041-NP $950
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  • * For Profit (FP) price is for non-academic, private companies and institutes
  • ** Non Profit (NP) price is for academic, non profit organizations and institutes

Kinase TAD Luciferase Reporter Vectors

Benefits:

  • Two-in-one - Gal4-TAD fusion protein and UAS-luciferase reporter combined into a single vector.
  • Functional assay - Monitor kinase activity in cells.
  • Quantitative analysis - Determine kinase activation by quantitative measurement of  luciferase activity.
  • Stable cell line generation The vectors can be used for establishing stable cells expressing the reporters.
Product Name Catalog # Price   Qty
ATF2-TAD Luciferase Reporter Vector LR-7001 $379
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cJUN-TAD Luciferase Reporter Vector LR-7002 $379
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CREB-TAD Luciferase Reporter Vector LR-7003 $379
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ELK-TAD Luciferase Reporter Vector LR-7004 $379
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HIF-TAD Luciferase Reporter Vector LR-7005 $379
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NRF2(113)-TAD Luciferase Reporter Vector LR-7006 $379
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NRF2(370)-TAD Luciferase Reporter Vector LR-7007 $379
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RelA(p65)-TAD Luciferase Reporter Vector LR-7008 $379
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Stat3-TAD Luciferase Reporter Vector LR-7009 $379
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Stat5b-TAD Luciferase Reporter Vector LR-7010 $379
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CMV Empty Vector LR-7500 $379
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AKT (WT) LR-7501 $379
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AKT (CA) LR-7502 $379
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AKT (DN) LR-7503 $379
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MEKK LR-7504 $379
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MAPK1 LR-7505 $379
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ROCK1-N LR-7506 $379
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ROCK1-C LR-7507 $379
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PKA LR-7508 $379
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MEK3 LR-7509 $379
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p38 MAPK (WT) LR-7510 $379
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p38 MAPK (CA) LR-7511 $379
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p38 MAPK (DN) LR-7512 $379
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GSK3b LR-7513 $379
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Signaling Protein Assay Kits

  • SH2 Domain-Based RTK Profiling Plate Array
  • Genome-Wide SH2-Domain GST Fusion Proteins
 
Product Name Catalog # Price   Qty
SH2 Domain-Based RTK Profiling Plate Array DA-0001 $519
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